Improvement of Endothelial Dysfunction in Acromegaly after Transsphenoidal Surgery
نویسندگان
چکیده
منابع مشابه
Endothelial Dysfunction in Patients with Acromegaly
Acromegaly is associated with a two-threefold increase in cardiovascular mortality compared to the normal population (1). Before the introduction of modern, effective therapeutic modalities, about 80% of these patients died before the age of 60 from cardiovascular disease (2). It is usually explained by the high prevalence of risk factors leading to atherosclerosis, such as hypertension, type 2...
متن کاملAcromegaly and transsphenoidal hypophysectomy: a case report.
Anterior pituitary tumors account for nearly 18% of all intracranial tumors. Pituitary adenomas that cause hypersecretion of growth hormone lead to acromegaly in adults. Patients with acromegaly may present unique problems for the anesthetist because of the overgrowth of airway soft tissues; a difficult mask ventilation and challenging intubation can be expected. A careful preoperative assessme...
متن کاملOlfactory outcomes after endoscopic transsphenoidal pituitary surgery.
BACKGROUND Olfaction has been demonstrated to have a great impact on patients' lives. Transsphenoidal endoscopic pituitary surgery is associated with potentially significant damage to olfactory tissues, but to date this issue has been only poorly documented in the literature. STUDY DESIGN Prospective cohort study comparing olfactory outcomes pre- and postpituitary surgery. METHOD Patients w...
متن کاملRisk factors for meningitis after transsphenoidal surgery.
To evaluate possible risk factors for meningitis, we retrospectively reviewed 228 transsphenoidal operations (in which a standard regimen of amoxicillin prophylaxis was used) for sellar pathology. The incidence of meningitis was 3.1% (seven of 228 cases). Cultures of preoperative specimens from the anterior nasal vestibule in three of seven patients yielded Staphylococcus aureus, but none of th...
متن کاملImpact of successful transsphenoidal surgery on cardiovascular risk factors in acromegaly.
BACKGROUND Cardiac abnormalities develop in patients with acromegaly as a consequence of effects of GH/IGF-I on the heart and related cardiovascular risk factors. OBJECTIVE To evaluate the possible contribution of postoperative variations in blood pressure (BP), glucose tolerance and insulin sensitivity to the cardiac improvement reported in patients who have been cured of acromegaly. DESIG...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2008
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.k07e-125